ScienceNode
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Interplay of medicine, chemistry, biology, and technology #STEM #FOAMed

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Last Notes

2024-11-11 17:02:24

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Thank you for the zap. ⚡️

2024-11-11 16:49:45

Should you be able to experiment on your own cancer? Virologist Beata injected a measles virus every few days into her tumor. But science journals were not happy. Why?
Read full #thread here: https://threadreaderapp.com/thread/1855386101885870143.html https://image.nostr.build/e04c2206ffc1db99d9e19b0bb4c6102fd06c7fe0a68f431bd87532d291ad5458.jpg https://image.nostr.build/406cf8a5a37a71fc601970cec5d53c4ee002e750d5ed12e4663a22b143081d09.jpg

2024-10-31 05:25:06

AI Radiology.
There is great potential for advancing AI recognition in the realm of health tech.
Amazon is already making great strides here, and more competition ideally yields accelerated quality and an elevated standard of global public health.
#Sirona, built with #AWS and compatible with #Chrome & #AppleVisionPro, is an innovation to empower—not replace—radiologists.
#NextDimensions in #Medicine
#HealthAccelerationism
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2024-10-31 05:04:26

#radiology #xray #radiologia #medicine #radiologist #medical #mri #radtech #xraytech #radiographer #doctor #healthcare #radiologytech #imaging #xrays #radiologylife #radiologystudent #ct #ctscan #medicalimaging #ultrasound #hospital #surgery #nurse #medstudent #xraystudent #medicina #medicalstudent #pathology
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2024-10-31 05:03:52

Common brain lesions on FLAIR MRI
Fluid-attenuated inversion recovery (FLAIR) is an MRI sequence with an inversion recovery set to null fluids. For example, it can be used in brain imaging to suppress cerebrospinal fluid (CSF) effects on the image, so as to bring out the periventricular hyperintense lesions.
The FLAIR sequence analysis has been especially useful in the evaluation and study of CNS disorders, involving:
● Lacunar infarction
● Multiple sclerosis (MS) plaques
● Subarachnoid haemorrhage
● Head trauma
● Meningitis and other leptomeningeal diseases
#medical #clinical #radiology #neurology #doctor
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2024-10-29 21:32:37

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2024-10-29 06:52:41

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2024-10-29 06:51:47

The Biden Administration delivered on a major milestone in lowering drug costs for seniors – with Medicare announcing the first 10 drugs selected for price negotiation.
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2024-10-29 06:43:32

#Entamoeba #histolytica
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2024-10-29 06:41:33

The virus was first detected in Trinidad and Tobago in 1955. Italy reported its first-ever case of Oropouche in June 2024, the first case to be detected in continental Europe.
#note1w4k…53kg
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2024-10-29 06:41:16

Death in Brazil: Oropouche virus disease is transmitted through the bites of infected Culicoides paraensis midges. "There have been no reports in the world's scientific literature of deaths from the disease."
https://www.dw.com/en/death-in-brazil-what-is-oropouche-fever/a-69466634?maca=en-rss-en-top-1022-rdf
#note17ee…046x

2024-10-29 06:38:04

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2024-10-29 06:37:08

Insurers collected $50 billion extra from Medicare by making questionable diagnoses, often without the knowledge of patients or their doctors.
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2024-10-29 06:35:31

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2024-10-27 02:37:38

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Felzartamab is an investigational therapeutic human monoclonal antibody directed against CD38.
#note126t…4asv

2024-10-25 02:09:34

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2024-10-20 17:43:45

𝐄𝐧𝐡𝐚𝐧𝐜𝐞𝐝 𝐖𝐨𝐮𝐧𝐝 𝐇𝐞𝐚𝐥𝐢𝐧𝐠
ROS include highly reactive substances such as superoxide anion (O2•−), hydrogen peroxide (H2O2), and the hydroxyl radical (•OH). The presence of flavonoids, terpenes, carotenoids, chlorophylls, and phytosterols contributes to anti-inflammatory effects.
https://www.mdpi.com/1999-4923/16/10/1277?#
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2024-10-17 23:03:06

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Yes, it sounds like we had the same experience. It took me a long time to figure out how to get logged in also and then the pink delete buttons wouldn't switch to grey, and I am still not sure what made it start working other than sheer willpower and switching browsers. When it's working, the bullet points next to each relay will change colors.

2024-10-17 20:49:30

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Relatable. I accidentally reposted something because I was sleepy, so I found out that Nos Social (beautiful UI) and Nostur have this option to delete, or we can log in to https://use.nsec.app/ and then paste the note ID into https://delete.nostr.com
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2024-10-17 04:18:41

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What's the point of building on sand?

2024-10-16 19:51:56

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Meanwhile I am eating cheddar cheese, ground beef, and whole egg fried in butter.

2024-10-16 03:29:33

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רֵאשִׁ֣ית חׇ֭כְמָה קְנֵ֣ה חׇכְמָ֑ה וּבְכׇל־קִ֝נְיָנְךָ֗ קְנֵ֣ה בִינָֽה׃
The beginning of wisdom is this: Get wisdom. With all your acquisitions, acquire discernment.

2024-10-15 00:03:28

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Adjusted measures of association can give a more accurate estimate of the true relationship between the exposure and the outcome, because they take into account the effect of confounders by statistically controlling for them.
https://www.researchgate.net/figure/Crude-and-adjusted-measures-of-association-between-suspected-risk-factors-and-MDD_fig1_330219624
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2024-10-15 00:01:46

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There are two main types of measures of association: crude and adjusted. Crude measures of association are based on the raw data and do not take into account any confounding factors.
⛀ Boston University School of Public Health
https://sphweb.bumc.bu.edu/otlt/mph-modules/bs/bs704-ep713_confounding-em/bs704-ep713_confounding-em_print.html
⛀ Effect Modification Flashcards
https://quizlet.com/412490992/effect-modification-flash-cards/
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2024-10-14 23:43:14

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Exempli gratia:
1) https://open.oregonstate.education/epidemiology/chapter/effect-modification/
2) https://www.japi.org/r2e4e454/measures-of-association
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2024-10-14 23:40:21

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Confounders can make it difficult to determine the true relationship between the exposure and the outcome, because they can create the semblance of a more direct association that is not actually present.
https://www.researchgate.net/post/Moderated_mediation_with_two_independent_variables
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2024-10-14 23:38:08

Confounding occurs when the relationship between an exposure (such as a risk factor or treatment) and a disease or outcome is distorted by the presence of another factor (called a confounder).
#ChatGPT #FOAMed
https://journals.sagepub.com/doi/full/10.1177/25152459221095827
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2024-10-13 16:55:11

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Ready for a comprehension quiz?
✎ https://archive.cdc.gov/#/details?url=https://www.cdc.gov/csels/dsepd/ss1978/lesson1/quiz.html
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2024-10-13 16:52:30

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When designing a clinical #trial, considering the natural history of a disease is fundamental to ensuring that the trial is adequately #powered to detect any differences between the novel treatment and #control groups.
✶ https://premier-research.com/perspectives/patient-registries-and-natural-history-studies/
✶ https://www.evidera.com/natural-history-studies-in-rare-diseases-and-genetic-biomarkers/
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2024-10-13 16:47:07

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A #cohort study is the best way to identify natural history of a disease; However, this type of study is less useful for examination of rare events or those that take a long time to develop.
✶ Comparison of Prospective Natural History Study Designs
https://pubmed.ncbi.nlm.nih.gov/11830217/
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2024-10-13 16:44:01

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By understanding the natural history of a disease, physicians, researchers, and epidemiologists can better determine the #impact that a treatment is having on the disease compared to the progression of a patient left to their own devices.
✶ https://www.semanticscholar.org/paper/Application-of-Disease-Etiology-and-Natural-History-White/d9d4949e275e5034878deddd108c1422cd2acdd7
✶ https://heart.bmj.com/content/95/7/524
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2024-10-13 16:34:18

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For example, the latency period for #leukemia to become evident among survivors of the #atomicbomb blast in #Hiroshima ranged from 2 to 12 years, peaking at 6–7 years.
✶ (CDC Table 1.7)
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2024-10-13 16:31:40

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#Subclinical disease, extending from the time of #exposure to #onset of disease symptoms, includes the #incubation period and the #latency period.
✶ https://www.researchgate.net/figure/Schematic-of-disease-natural-history-model_fig4_305324845
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2024-10-13 16:29:12

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This includes the #progression of the disease, the symptoms that are experienced, and the #outcomes that are typically seen.
✶ https://link.springer.com/chapter/10.1007/978-0-387-93835-6_5/figures/5_2_147978_1_En
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2024-10-13 16:26:54

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The #naturalhistory of a disease refers to the course that the disease takes in the absence of any treatment.
✶ Natural History of Disease Timeline:
https://archive.cdc.gov/#/details?url=https://www.cdc.gov/csels/dsepd/ss1978/lesson1/section9.html (CDC Principles of epidemiology, 2nd ed.)
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2024-10-13 16:10:19

When evaluating the effectiveness of a drug, it is important to consider the natural history of the disease.
(#FOAMed written by #ChatGPT)
#ClinicalTrials #Medstr
✶N. gonorrhoeae infection
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.03187/full
✶Huntington disease
https://www.ncbi.nlm.nih.gov/books/NBK1305/figure/huntington.F1/
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2024-10-13 16:02:17

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Content and Photographs by Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, California 92093-0611.

2024-10-13 15:59:57

Get a comprehensive review of systems for adult patients with the #AdultROS at https://meded.ucsd.edu/clinicalmed/ros.html
Discover the most common symptoms, associated disorders, and red flags for each organ system. Use this guide for a more informed decision making in your patient care strategy. #PatientCare #ClinicalMedicine #Healthcare #Diagnosis
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2024-10-13 15:54:44

Use Digital #DDx to see #differentials based on 1000s of #symptoms. The schema presented lend organization and clarity to the #clinical reasoning process.
#Sx
digitalddx.com/symptoms_list/
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2024-10-12 18:33:57

Medical and surgical #residencies.
You can find a more comprehensive #specialty list at:
https://freida.ama-assn.org/specialty
Honorable mentions:
#Surgery—Colon and Rectal Surgery
#Medicine—Preventive Medicine
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2024-10-11 09:02:07

#note1vke…zhsp
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2024-10-10 14:17:22

Swept Under Death's Rug
Donald Trump Told Me #Disabled Americans Like My Son 'Should Just Die'
"[M]any disabled people don't want this & our voices are rarely heard. That's why I made this".
In Canada, #MAiD has been in effect for some time. The poor, disabled, substance users, mentally unwell, elderly, homeless & long-term sick have been directed to MAiD, rather than receive any #support from Canadian Gov. The UK plan will look something like this, according to a citizen of the UK.
https://www.bbc.co.uk/iplayer/episode/m001z8wc/better-off-dead
https://time.com/7002003/donald-trump-disabled-americans-all-in-the-family/
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2024-10-09 21:05:01

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2024-10-09 18:38:17

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Yipee

2024-10-09 18:36:57

Protein #Bioinformatics
This year’s chemistry laureates Demis Hassabis and John Jumper have developed an AI model, #AlphaFold2, to solve a 50-year-old problem: predicting proteins’ complex structures.
#NobelPrize
𝗪𝗵𝗮𝘁 𝗶𝘀 𝗮 𝗣𝗿𝗼𝘁𝗲𝗶𝗻? Learn about the 3D shape and function of macromolecules from the Protein Data Bank (#PDB).
https://youtu.be/qBRFIMcxZNM
Introduction to #𝗰𝗿𝘆𝘀𝘁𝗮𝗹𝗹𝗼𝗴𝗿𝗮𝗽𝗵𝘆 through cartoons from the Royal Institution
https://youtu.be/gLsC4wlrR2A
Protein Alphabet Shapes: #HowarthLab
http://www.howarthgroup.org/alphabet
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2024-10-07 16:07:03

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μηκέτι ὑδροπότει ἀλλὰ οἴνῳ ὀλίγῳ χρῶ διὰ τὸν στόμαχον καὶ τὰς πυκνάς σου ἀσθενείας
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2024-10-07 13:12:50

MedLM for the healthcare industry
Med-PaLM harnesses the power of Google’s large language models, which we have aligned to the medical domain and evaluated using medical exams, medical research, and Google searches related to health. #MedPaLM2 was the first to reach human expert level on answering #USMLE-style questions. https://sites.research.google/med-palm/
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2024-10-06 17:25:49

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ὃς μὲν πιστεύει φαγεῖν πάντα ὁ δὲ ἀσθενῶν λάχανα ἐσθίει:
One person’s faith allows them to eat anything, while the weak person eats only herbs.
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2024-10-06 07:41:52

Healthcare R&D Tax Credit
Open source software can help. Data is not yet collected in granular enough form, and with enough accuracy and consistency, to support stratification. We can't even measure one of the most basic health metrics accurately.
Open Health News is a news, information, and resource portal on all things related to 'Open Health' - i.e. #opensource, #openaccess, #opendata, #openarchitecture, #openstandards, and #opencommunities in #healthcare.
https://www.openhealthnews.com/articles/2014/three-areas-where-health-information-technology-needs-get-its-house-order