Mark Baxter 🏳️‍🌈💉🧂 / is on Nostr

Neuroscientist interested in brain mechanisms of learning and memory. NHP anesthesiologist. 🏳️‍⚧️ Trans rights are human rights. He/him. 🏳️‍🌈

Last Notes

2023-09-01 21:40:24

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@npub1skv…aky3 @npub1u2v…4999 I'll also tip my hat to my friend and colleague Nick Gilpin on the other site, who sums up the stakes nicely.
https://neuromatch.social/system/media_attachments/files/110/992/059/252/707/686/original/e7386e9a83018f59.jpeg

2023-09-01 19:44:48

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@npub1skv…aky3 @npub1u2v…4999 yes yes this exactly! I can understand, I suppose, the interest in describing a circuit/network at finer levels of resolution. But most "circuit neuroscience" papers read like "we found two brain areas we already know are involved in a very simple behavioral task in mice, and we put all the techniques we could get to work in a blender and produced three figures with 20 panels each"

2023-09-01 19:44:48

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2023-09-01 19:30:55

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@npub1u2v…4999 @npub1skv…aky3 I feel this deep in my soul. I think almost all of the "circuit" work that has been done using BRAIN initiative funded technology has just been an engine for producing Cell and Nature papers with tiny data figures and has generated virtually no new insight into how the brain works.

2023-09-01 19:30:55

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2023-09-01 14:34:47

In the unusual position of having a group of biostatisticians chasing us to publish a letter where they've reanalyzed some of our published data to get "better" p-values, so it seems like not everyone has heard about p-hacking (I am very comfortable with the analytic strategy we used)