Oh, this is very interesting. Hints (much more research needed) as to why autoimmune conditions disproportionately affect women, in as much as an 80-20 division.
https://phys.org/news/2024-02-lupus-autoimmune-diseases-women-men.html
One reason this is a “new” discovery? Mechanism relates to a type of RNA specific to cells with 2 X chromosomes. And as the article states: "standard tests for autoimmunity were made using male cells.” 😖