When designing a clinical #trial, considering the natural history of a disease is fundamental to ensuring that the trial is adequately #powered to detect any differences between the novel treatment and #control groups.
✶ https://premier-research.com/perspectives/patient-registries-and-natural-history-studies/
✶ https://www.evidera.com/natural-history-studies-in-rare-diseases-and-genetic-biomarkers/