> The furin cleavage site consists of four amino acids PRRA, which are encoded by 12 inserted nucleotides in the S gene. A characteristic feature of this site is an arginine doublet.
>
> This insertion could have occurred by random insertion mutation, recombination or by laboratory insertion. The researchers say the possibility of random insertion is too low to explain the origin of this motif.
>
> Surprisingly, the CGGCGG codons encoding the two arginines of the doublet in SARS-CoV-2 are not found in any of the furin sites in other viral proteins expressed by a wide range of viruses.
>
> Even within the SARS-CoV-2, where arginine is encoded by six codons, only a minority of arginine residues are encoded by the CGG codon. Again, only two of the 42 arginines in the SARS-CoV-2 spike are encoded by this codon – and these are in the PRRA motif.
random MD's essay https://archive.fo/nxMNr
clawfulneutral /
npub16r…3m8vh
2025-01-26 01:38:54
in reply to nevent1q…hyj9
Author Public Key
npub16rpnyh6ezdusnyap2l42l83sz8cugvkr4f5jyx6n6s60sz0kyexse3m8vhPublished at
2025-01-26 01:38:54Event JSON
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"content": "\u003e The furin cleavage site consists of four amino acids PRRA, which are encoded by 12 inserted nucleotides in the S gene. A characteristic feature of this site is an arginine doublet.\r\n\u003e \r\n\u003e This insertion could have occurred by random insertion mutation, recombination or by laboratory insertion. The researchers say the possibility of random insertion is too low to explain the origin of this motif.\r\n\u003e \r\n\u003e Surprisingly, the CGGCGG codons encoding the two arginines of the doublet in SARS-CoV-2 are not found in any of the furin sites in other viral proteins expressed by a wide range of viruses.\r\n\u003e \r\n\u003e Even within the SARS-CoV-2, where arginine is encoded by six codons, only a minority of arginine residues are encoded by the CGG codon. Again, only two of the 42 arginines in the SARS-CoV-2 spike are encoded by this codon – and these are in the PRRA motif.\r\n\r\nrandom MD's essay https://archive.fo/nxMNr",
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