npub13rqpd7a4hap9af2cpe5qvfqqrxsmrjjdy9f9rj7m9t3x3gdcq77q5l4knd (npub13rq…4knd)
Such beautiful work! Tremendous congratulations to npub13rqpd7a4hap9af2cpe5qvfqqrxsmrjjdy9f9rj7m9t3x3gdcq77q5l4knd (npub13rq…4knd) and team.
Fascinating:
We identify many instances of dense-core-vesicle-dependent signalling, including on timescales of less than a second, that evoke acute calcium transients—often where no direct wired connection exists but where relevant neuropeptides and receptors are expressed. We propose that, in such cases, extrasynaptically released neuropeptides serve a similar function to that of classical neurotransmitters.
Also happy to see this confirmed:
Finally, our measured signal propagation atlas better predicts the neural dynamics of spontaneous activity than do models based on anatomy.